It refers to an isolated antibody, which is connected with latent growth difference factor 8 (myopia), which is characterized by inhibition of myokinesis; the antibody blocks the release of mature myosin from latent myopia, blocks the protein release of mature myosin, and blocks the spontaneous release of mature myosin. From the mature mistatina, it will not join the mature mistatina,O add epilepsy in a fraction of carbamate 21-100 (SEQ ID No: 78). The description also provides beliefs about polypeptides and variants containing a region and methods of developing and using these substances. In addition, nucleic acids are provided to encode polypeptides and stellar cells, including nucleic acids. He also mentioned a way to express pharmacologySe refiere a un anticuerpo aislado que se une al factor de diferenciacion de crecimiento 8 (miostatina) latente, caracterizado porque inhibe la activacion de miostatina; el anticuerpo bloquea la liberacion de miostatina madura a partir de miostatina latente, bloquea la liberacion proteolitica de miostatina madura, bloquea la liberacion espontanea de miostatina madura, no se une a miostatina madura, o se une a un epItopo dentro de un fragmento que consiste de los aminoacidos 21-100 del propeptido de miostatina (SEQ ID NO: 78). La descripcion tambien proporciona polipeptidos que contienen una region Fe variante y metodos para elaborar y usar los mismos. Tambien se proporcionan acidos nucleicos que codifican los polipeptidos y celulas hospederas que comprenden los acidos nucleicos. Tambien se refiere a una formulacion farmaceutica que la comprende