PROBLEM TO BE SOLVED: To provide an angiotensin-converting enzyme inhibitor effectively inhibiting ACE(angiotensin-converting enzyme) with a small amounts of its uptake, and being safe with no concern about any side effects, and to provide food, pharmaceuticals and feed each compounded therewith and to provide a method for producing the inhibitor.SOLUTION: The angiotensin-converting enzyme inhibitor includes: a peptide composed of either one of amino acid sequences represented by the following structural formulas (1) to (4) or at least one of these peptides, wherein the structural formulas (1) to (4) are as follows: (1) Ala-Gly-Tyr-Glu, (2) Thr-Ala-Tyr, (3) Val-Lys-Ala-Pro, and (4) Gly-Glu-Tyr. By being compounded with food, pharmaceuticals and feed, this inhibitor, with high safety, enables continuous uptake of its own, for the purpose of preventing hypertension and easing hypertensive tendency or blood pressure regulation. This inhibitor is obtained by making a protease act on phyto- or animal-material tissue containing the amino acid sequence or on a protein extracted from the tissue.COPYRIGHT: (C)2012,JPO&INPIT【課題】少量の摂取でACEを有効に阻害し、かつ副作用の心配が少ない安全なアンジオテンシン変換酵素阻害剤、ならびにそれを配合した食品、医薬品および飼料並びにその製造方法を提供する。【解決手段】下記の構造式(1)~(4)で表されるいずれかのアミノ酸配列からなるペプチド又は前記ペプチドの少なくとも1種を含有するアンジオテンシン変換酵素阻害剤、食品、医薬品、飼料とすることにより、安全性に優れ、高血圧症の予防、高血圧傾向の緩和または血圧調節を目的として、継続的に摂取することが可能となる。前記アミノ酸配列を含む植物素材組織若しくは動物素材組織又は前記植物素材組織若しくは動物素材組織から抽出された蛋白質にプロテアーゼを作用させることにより得られる。(1)Ala-Gly-Tyr-Glu、(2)Thr-Ala-Tyr、(3)Val-Lys-Ala-Pro、(4)Gly-Glu-Tyr【選択図】なし
