Smiti Vaid Gupta,Enrique Martinez, II,Fazlul H. Sarkar,Denis M. Callewaert,Andreea Geamanu,Kevin Michael Patrie,Tiffany Capri Thomas,Andrew A. Dahl
申请号：
US13580471
公开号：
US09486005B2
申请日:
2011.02.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogs of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
