Provided herein are novel sirtuin-modulating compounds of formula:(see formula II)The sirtuin-modulating compoundsmay be used for increasing the lifespan of acell, and treatingand/or preventing a wide variety of diseases and disorders including,forexample, diseases ordisorders related to aging or stress, diabetes, obesity, neurodegenerativediseases, cardiovasculardisease, blood clotting disorders, inflammation, cancer, and/or flushing aswell as diseases ordisorders that would benefit from increased mitochondrial activity. Alsoprovided arecompositions comprising a sirtuin-modulating compound in combination withanothertherapeutic agent.
