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APPLICATION OF THE ALBIZZIA CHINENSIS EXTRACT FOR THE PRODUCTION OF A MEDICINE FOR TREATMENT OF A STOMACH ULCER
专利权人:
ИНСТИТЬЮТ ОФ МАТЕРИЯ МЕДИКА; ЧАЙНИС АКЭДЕМИ ОФ МЕДИКАЛ САЙЕНСИЗ (CN)
发明人:
ЮЙ Шишань (CN),ЧЖАН Цзяньцзюнь (CN),МА Шуанган (CN),СЮЙ Жуймин (CN),ЦЗИ Чэнсюэ (CN)
申请号:
RU2014116582/15
公开号:
RU2014116582A
申请日:
2012.10.24
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of obtaining an extract of Albizzia chinensis (Osbeck) Merr (Chinese albicia), comprising the following stages: A. drug material Albizzia chinensis (Osbeck) Merr extracted with a solvent; and. extract Albizzia chinensis using column chromatography with a polyamide adsorbent, eluting with a gradient of solvents. 2. The production method according to claim 1, characterized in that, in step A, said solvent is selected from an alcohol solvent or a mixed solvent based on water and alcohol. The production method according to claim 2, characterized in that said step A comprises the following stages: one kilogram of crushed bark of Albizzia chinensis is extracted with 3-5 liters of 80-95% EtOH in HO by heating under reflux 2-4 times (each time heating within 2-3 hours); the liquid extract is collected and then the solvent is removed under reduced pressure to obtain the extract. 4. The production method according to claim 1, characterized in that said stage B comprises the following stages: the extract obtained in stage A is dissolved in 10-30% EtOH in HO and then subjected to column chromatography on a polyamide adsorbent with a size of 30-90 mesh, this volume / mass (l / kg) the ratio of the powder of the polyamide adsorbent to the extract of Albizzia chinensis is 25: 1-30: 1, 10-30% and 40-80% EtOH in HO are eluted sequentially, while the volume of the eluting solution is 3-5 times the amount of polyamide; a solution eluted with 40-80% EtOH was concentrated to obtain an extract of Albizzia chinensis. 5. Albizzia chinensis extract obtained by the method according to any one of claims. 1-4.6. A pharmaceutical composition comprising an effective amount of an extract of Albizzia chinensis no. 5 and a pharmaceutically acceptable carrier. The use of Albizzia chinensis extract according to claim 5 as a1. Способ получения экстракта Albizzia chinensis (Osbeck) Merr (альбиции китайской), включающий следующие стадии:А. лекарственный материал Albizzia chinensis (Osbeck) M
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