It possesses at least one of cell breeding promotion activity, vascular new life promotion activity, lumen formation promotion activity, cell migration promotion activity and nervous cell growth promotion activity, stability it is the low-molecular material chemically, because of the low-molecular tonnage, absorptivity is high, stabilizing cheaply, offers supply possible chemical compound. The shikurobuchirupurin derivative of this invention, the tautomerization isomer or stereoisomer, or those salts, the solvent dishes dressed with sauce or the hydrate, is displayed with the below-mentioned general formula (1) the shikurobuchirupurin derivative which, that tautomerization isomer or stereoisomer, or those salts, are the solvent dishes dressed with sauce or the hydrate.細胞増殖促進活性、血管新生促進活性、管腔形成促進活性、細胞遊走促進活性および神経細胞成長促進活性の少なくとも一つを有し、化学的に安定な低分子物質であり、低分子量のため、吸収性が高く、安価に安定して供給可能な化合物を提供する。本発明のシクロブチルプリン誘導体、その互変異性体もしくは立体異性体、またはそれらの塩、溶媒和物もしくは水和物は、下記一般式(1)で表されるシクロブチルプリン誘導体、その互変異性体もしくは立体異性体、またはそれらの塩、溶媒和物もしくは水和物である。
