The invention relates to a solid dispersion comprising Coenzyme Q 10 and a phospholipid, in the presence of a cellulosic derivative and/or a polymeric material belonging to the groups of oligo and polysaccharides, linear and/or cross-linked polymers of N-vinyl-2-pyrrolidone, linear polymers of vinyl alcohol, polymers of vinyl acetate, co-polymers of methacrylic acid and ethyl acrylate, co-polymers of ethylene oxide and propylene oxide, polyethylene glycols.