#$%^&*AU2016200971A120160303.pdf#####ABSTRACT Methods of reducing one or more side-effects associated with treatment with nitazoxanide or tizoxanide in a patient are provided, the method comprising administering to the patient a therapeutically effective amount of a pharmaceutical composition in the form of a solid dosage form, the composition comprising: (a) a first portion comprising a first quantity of nitazoxanide, tizoxanide or a pharmaceutically acceptable salt or ester thereof in a controlled release formulation； and (b) a second portion comprising a second quantity of nitazoxanide, tizoxanide or a pharmaceutically acceptable salt or ester thereof in an immediate release formulation, wherein the one or more side effects is related to an intestinal tract. Methods of using the pharmaceutical composition for increasing the bioavailability of nitazoxanide or an analogue thereof in a patient are also provided. 7305619_1 (GHMatters) P87871.AU.1 RDAULTON
