DE VRY, JEAN-MARIE-VICTOR DR,DRESSEL, JUERGEN DR,FRANZ, JUERGEN,FRIEDL, ARNO DR,HORVATH, ERVIN,JORK, REINHARD DR,KELDENICH, JOERG,MATZKE, MICHAEL DR,MAULER, FRANK DR,MITTENDORF, JOACHIM,MOHRS, KLAUS-H
申请号：
HU0001111
公开号：
HU228509B1
申请日:
1998.02.10
申请国别(地区):
HU
年份:
2013
代理人:
摘要：
Aryl sulphonamides (I) and their salts are new: R1-A-D-E-G-L-R2 (I) R1 = 6-10C aryl； quinolyl； isoquinolyl； or a group of formula (a)； Q = group of formula (i)-(vii): a = 1 or 2； R3 = H； 2-6C alkenyl； 1-6C alkyl； 1-6C acyl； -(CO)b-NR4R5 or -NR6-SO2-R7； b = 0 or 1； R4, R5 = H； phenyl； 1-6C acyl； 4-7C cycloacyl； benzoyl； or 1-6C alkyl optionally substituted by NH2, NH(1-6C alkyl) or N(1-6C alkyl)2； or NR4R5 = 5- or 6-membered saturated heterocycle optionally containing S and/or O and/or NR8； R6 = H； phenyl； 1-6C alkyl； or 1-6C acyl； R7 = phenyl or 1-6C alkyl； R8 = H； 1-6C alkyl； or 1-6C acyl； rings in R1 and alkenyl, alkenyl and acyl groups in R3 are optionally geminally substituted by 1 or more halo, COOH, OH, phenyl, 1-6C alkoxy, 1-6C alkoxycarbonyl or 1-8C alkyl (itself optionally substituted by halo, 1-6C alkylsulphonyloxy, N3, NH2, NH(1-6C alkyl), N(1-6C alkyl)2 or OH)； A, E = bond or 1-4C alkylene； D = O ； S(O)c； or N(R9)； c = 0-2； R9 = H； 1-6C alkyl； or 1-6C acyl； G = divalent 6-10C aryl or 5-7-membered heteroaryl (containing 1-3 S, N and/O) optionally substituted by 1 or more OH, CF3, COOH, halo, 1-6C alkyl, 1-6C hydroxyalkyl, 1-6C alkoxy, 1-6C alkoxycarbonyl, -CO-O-(CH2)d-NR4R5, -NR6-SO2R7, -(CH2)e-(CO)f-NR14R15 and/or OR16； R14, R15 = R4 and R5 or -(CH2)g-NR4R5； d, g = 1-4； e, f = 0 or 1； R16 = 6-10C aryl； L = O； NH； N(R19)-SO2； N(R20)-SO； N(R21)-SO2O； N(R22)-SO2-N(R23)； N(R24)-CO； SO2-N(R25)； OSO2； N(R26)-P(O)(OR27)； or N(OH)-SO2 (bonding to G is via the left hand atom)； R19-R27 = H or 1-4C alkyl or R19 = SO2R2； R2 = 6-10C aryl or 5-7-membered saturated or aromatic heterocycle (containing 1-3 S, N and/or O) optionally substituted by 1 or more halo, CF3, NO2, NH2 and/or 1-6C alkyl； a group of formula (b): morpholinyl； 3-8C cycloalkyl； 1-12C alkyl, 2-12C alkenyl or 2-12C alkynyl optionally substituted by 1 or more halo, CF3, OH, CN, N3, 1-6C alkoxy (optionally substituted by 1 or more F)； phthalimido and/or NR4R5； or phenyl or 5- or 6-membered heteroaryl (con
