JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES;TORAY INDUSTRIES, INC.
发明人:
WAKITA, TAKAJI,MURAYAMA, ASAKO,KATO, TAKANOBU
申请号：
CA2837279
公开号：
CA2837279A1
申请日:
2012.05.31
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention provides a nucleic acid containing a hepatitis C virus J6CF strain genome 5'-untranslated region, a virus protein coding region containing an NS3 protein coding sequence, an NS4A protein coding sequence, an NS4B protein coding sequence, an NS5A protein coding sequence and an NS5B protein coding sequence, and a 3'-untranslated region, in order from the 5' side to the 3' side. Therein, the NS4A protein coding sequence has a mutation substituting glutamic acid for the 1680th alanine, when the amino acid sequence of a J6CF strain precursor protein is used as a reference.
