Mutant replicon derived from hepatitis C virus J6CF strain genome

• 收藏
• 分享

专利权人:

国立感染症研究所長;東レ株式会社

发明人:

脇田 隆字,村山 麻子,加藤 孝宣

申请号：

JP2013518156

公开号：

JP5927185B2

申请日:

2012.05.31

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

This invention provides a nucleic acid comprising the 5' untranslated region, a virus protein-coding region including the NS3 protein coding sequence, the NS4A protein coding sequence, the NS4B protein coding sequence, the NS5A protein coding sequence, and the NS5B protein coding sequence, and the 3' untranslated region of the HCV J6CF genome in that order from the 5' to 3' direction. The NS4A protein coding sequence has a mutation for substituting alanine at position 1680 with glutamic acid, as determined on the basis of the amino acid sequence of the precursor protein of the J6CF strain.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/