ZDZALIK, Daria,LIPNER, Joanna,WIECZOREK, Maciej,DZWONEK, Karolina,YAMANI, Abdellah,DUBIEL, Krzysztof,LAMPARSKA-PRZYBYSZ, Monika,GRYGIELEWICZ, Paulina,STANCZAK, Aleksandra
申请号：
ES14712781
公开号：
ES2622376T3
申请日:
2014.03.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound represented by the general formula (1) ** Formula ** in which the hydrogen atoms shown attached to pyrazole and benzimidazole rings are attached to one of the nitrogen atoms of the pyrazole or benzimidazole ring, respectively； R 1 represents -XOP, in which X is absent or represents -CH2-, -C (O) -, or -e (O) NH- (eH2k, where k is 0, 1 or 2； O is selected from the group consisting of 01, 02, 03, 04 and 05, in which ** Formula ** Q1 is in which A represents -eH- or a nitrogen atom, and B represents -eH-, an oxygen atom O or a nitrogen atom, and when 01 represents piperazinylene, it can be optionally further substituted with two methyl groups in positions 3, 5； ** Formula ** Q2 is in which one of A 1, A2, A3, A4 And A5 represents a nitrogen atom, and the others represent C； ** Formula ** Q3 is where one of A5, A6, A7 and A8 represents a nitrogen atom, and the others represent C, especially Q3 is presented by Q31, ** Formula ** Q31 is where one of A5, A6 and A7 represents a nitrogen atom, and the others represent e； Q4 is ** Formula ** Q5 is ** Formula ** P is absent or represents C1-C3 straight or branched chain alkyl, - (CH2) I-NR2R3 or - (CH2 ) m-C (0) NR2R3, in which I and m independently of each other represent O, 1 or 2, with the proviso that when B in Q1 represents an oxygen atom, then P is absent； and R2 and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with the nitrogen atom to which they both bind form a 6-membered saturated heterocyclic ring in which one of the carbon atoms of said heterocyclic ring can optionally be replaced with -0-, -NH- or -N-(C1-C2) alkyl -； and acid addition salts thereofCompuesto representado por la fórmula general (1)**Fórmula** en la que los átomos de hidrógeno mostrados unidos a anillos de pirazol y bencimidazol están unidos a uno de los átomos de nitrógeno del anillo de pirazol o bencimidazol, respectivamente； R 1 representa -X-O-P, en el que X está ausente o representa -CH2-, -C(O)-, o -e(O)NH-(eH2k , e
