JAHANGIR, ALAM,SOTH, MICHAEL,YANG, HANBIAO,LYNCH, STEPHEN M.
申请号：
ES10755150
公开号：
ES2509590T3
申请日:
2010.09.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of Formula I in which: Q is phenyl or heteroaryl, optionally substituted with one or more Q '； Q 'is halogen, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, amino, C 1-6 alkoxy, or C 1-6 haloalkoxy； Q1 is O or C (Q1 ') 2； each Q1 'is independently H, halogen, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, amino, C 1-6 alkoxy, or C 1-6 haloalkoxy； Q2 is (C (Q2 ') 2) n, N (Q2 "), or C (Q2') 2C (Q2 ') 2； each Q2' is independently H, halogen, hydroxy, C1-6 alkyl, C1- haloalkyl 6, C1-6 hydroxyalkyl, amino, C1-6 alkoxy, or C1-6 haloalkoxy, or Q2 "and Q3 'together form a heterocyclic ring； n is 2, 3 or 4； Q3 is O, N (Q3 '), C (Q3') 2, carbocyclyl or heterocyclyl； each Q3 'is independently H, halogen, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, amino, C 1-6 alkoxy, phenyl, benzyl, or C 1-6 haloalkoxy； or both Q3 'together form a spirocyclic carbocyclic ring or heterocyclic ring； and Q4 is C (>； = O) or S (>； = O) 2； with the proviso that when Q2 is N (Q2 "), then Q3 is not N (Q3 '), or a pharmaceutically acceptable salt thereof.Un compuesto de Fórmula I en el que: Q es fenilo o heteroarilo, opcionalmente sustituido con uno o más Q'； Q' es halógeno, hidroxi, alquilo C1-6, haloalquilo C1-6, hidroxialquilo C1-6, amino, alcoxi C1-6, o haloalcoxi C1-6； Q1 es O o C(Q1')2； cada Q1' es independientemente H, halógeno, hidroxi, alquilo C1-6, haloalquilo C1-6, hidroxialquilo C1-6, amino, alcoxi C1-6, o haloalcoxi C1-6； Q2 es (C(Q2')2)n, N(Q2"), o C(Q2')2C(Q2')2； cada Q2' es independientemente H, halógeno, hidroxi, alquilo C1-6, haloalquilo C1-6, hidroxialquilo C1-6, amino, alcoxi C1-6, o haloalcoxi C1-6, o Q2"y Q3' juntos forman un anillo heterocíclico； n es 2, 3 ó 4； Q3 es O, N (Q3'), C(Q3')2, carbociclilo o heterociclilo； cada Q3'es independientemente H, halógeno, hidroxi, alquilo C1-6, haloalquilo C1-6, hidroxialquilo C1-6, amino, alcoxi C1-6, fenilo, bencilo, o haloalcoxi C1-6； o ambos Q3' juntos forman un anillo carbocíclico e
