Daniel Hunziker,Christian Lerner,Werner Mueller,Ulrike Obst Sander,Philippe Pflieger,Pius Waldmeier
申请号:
US13477217
公开号:
US08450313B2
申请日:
2012.05.22
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to compounds of formula Iwherein R1a to R1e, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.