Pius Waldmeier;Daniel Hunziker;Chrisitan Lerner;Ulrike Obst Sander;Philippe Pflieger;Werner Mueller
发明人:
Daniel Hunziker,Chrisitan Lerner,Werner Mueller,Ulrike Obst Sander,Philippe Pflieger,Pius Waldmeier
申请号：
US12727271
公开号：
US08268820B2
申请日:
2010.03.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds of formula Iwherein R1a to R1c, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
