Joerg Mattes,Paul Stephen Foster,Adam Collison,Luke Hatchwell
申请号：
US13885491
公开号：
US20130309238A1
申请日:
2011.11.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided herein are methods and compositions for modulating signal transduction pathways by regulating the expression and/or activity of Midline-1, enabling the inhibition of airways inflammation, the inhibition of airways hyperresponsiveness, the inhibition of rhinovirus-associated inflammation, and reductions in cytokine and chemokine release. Methods and compositions disclosed herein facilitate the treatment and prevention of conditions associated with airway inflammation, airway tissue remodelling and rhinovirus-associated inflammation and symptoms, manifestations and exacerbations thereof, in particular of allergic diseases such as allergic airways diseases including asthma.
