The present invention relates to a kind of pharmaceutical composition with what treatment, prevention or improvement premature ejaculation, the composition is taken on demand before sexuality, and the amount that the composition contains the clomipramine hydrochloride as active constituent is 14-16mg, preferably about 15mg. It is highly preferred that pharmaceutical composition of the invention also contains pregelatinized starch and sodium starch glycollate. The effect of pharmaceutical composition of the invention is capable of providing quick acting, while dissolution (absorption) deviation is reduced according to the gastrointestinal tract pH situation of patient and reduces side effect to minimum.本發明涉及一種用於治療、預防或者改善早泄的藥物組合物，該組合物在性活動前按需求服用，該組合物含有作爲活性成分的鹽酸氯米帕明的量爲14-16mg，優選約爲15mg。更優選地，本發明的藥物組合物還含有預膠凝澱粉和羥基乙酸澱粉鈉。本發明的藥物組合物能够提供快速起效的功效，同時根據患者的胃腸道pH狀况減少溶解（吸收）偏差以及使副作用減少至最小。
