PROBLEM TO BE SOLVED: To provide a new model animal of renal insufficiency condition, a method for creating the model animal, and a method for evaluating a medicament by using the model animal of the condition.SOLUTION: The model animal of the renal insufficiency condition is created by directly administering an anthracycline-based antitumor antibiotic to the kidney the method for creating the model animal and the method for evaluating the medicament by using the model animal of the condition are also provided, more particularly, the model animal of the renal insufficiency condition is created by directly administering doxorubicin hydrochloride to the kidney.COPYRIGHT: (C)2009,JPO&INPIT【課題】新規な腎不全病態モデル動物、その作製方法並びに該病態モデル動物を用いた薬物評価法を提供する。【解決手段】アンスラサイクリン系抗腫瘍性抗生物質を腎臓に直接投与して作製されることを特徴とする腎不全病態モデル動物、その作製方法、並びに該病態モデル動物を用いた薬物の評価法であって、より詳しくは塩酸ドキソルビシンを腎臓に直接投与して作製されることを特徴とする腎不全病態モデル動物、その作製方法並びに該病態モデル動物を用いた薬物の評価法。【選択図】なし
