PROBLEM TO BE SOLVED: To provide a production method of a non-human model animal with enhanced phosphorylation of tau protein enabling production simply and efficiently under a condition close to a physiologic condition, and usable for production of both models of a disease developed in a short period and a disease developed in a long period.SOLUTION: A production method of a non-human model animal with enhanced phosphorylation of tau protein includes a process for applying an intermittent low-oxygen load to a non-human animal.
