This invention provides a peptide with lipopolysaccharide binding activity and its use. The peptide comprises a lipopolysaccharide binding domain fragment which is selected from one of the following amino acid sequence: LPS-BD1 (SEQ ID NO: 9) or LPS-BD3 (SEQ ID NO: 10).本發明提供有一種具有脂多醣結合活性之胜肽及其用途,該胜肽包含有一脂多醣結合區片段,該片段係選自下列胺基酸序列之一:LPS-BD1(SEQ ID NO:9)或LPS-BD3(SEQ ID NO:10)。