Immunogeniczne peptydy WT-1 i sposoby ich użycia

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专利权人:

Sloan Kettering Institute For Cancer Research

发明人:

SCHEINBERG David, A.,MAY RENA

申请号：

PL07755205

公开号：

PL2010209T3

申请日:

2007.04.10

申请国别(地区):

PL

年份:

2017

代理人:

摘要：

An isolated, heteroclitic WT1 peptide, wherein the isolated peptide comprises the amino acid sequence SGQAYMFPNAPYLPSCLES (SEQ ID No: 41) and has one or more point mutations in a primary or secondary anchor residue of an HLA class I or class II binding motif, or the isolated peptide has at least 83% sequence identity with the amino acid sequence SEQ ID NO:41, or the isolated peptide is 20-26 amino acids in length and comprises the amino acid sequence SGQAYMFPNAPYLPSCLES (SEQ ID NO:41), or the isolated peptide is 17 or 18 amino acids in length and comprises a fragment of the amino acid sequence SGQAYMFPNAPYLPSCLES (SEQ ID NO:41). The peptide may be for use in treating a WT1-expressing cancer in asubject.

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