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DÉRIVÉS DE LA PIPÉRIDINE ET DE LA PYRROLIDINE DOTÉS D'UN ANTAGONISME POUR LES RÉCEPTEURS NPY Y5
专利权人:
Shionogi & Co.; Ltd.
发明人:
申请号:
EP10748839.7
公开号:
EP2404902A1
申请日:
2010.03.05
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention discloses novel piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention discloses a compound represented by the formula (I), a pharmaceutically acceptable salt or a solvate thereof:whereinA is substituted or unsubstituted monocyclic aryl or monocyclic heterocyclyl; X is a single bond or C(=O); Y is a single bond, CR5R6NR7 or C (=O) NR7; R1 and R2 are independently hydrogen or substituted or unsubstituted alkyl; R3 is substituted or unsubstituted aryl or heterocyclyl; R4 is halogen, substituted or unsubstituted alkyl, alkoxy, aryloxy or heterocyclyloxy, etc.; p is an integer of 0 to 2; q is 0 or 1; m is 0 or 1; n is an integer of 0 to 5; and B is aromatic carbocycle, monocyclic heterocycle or bicyclic fused hetero ring.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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