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LIPOSOME COMPOSITION AND PHARMACEUTICAL COMPOSITION
专利权人:
FUJIFILM Corporation
发明人:
Noriyuki KASAGI,Naoki YAMADA,Mikinaga MORI,Takayuki KATO,Takayuki KOBAYASHI
申请号:
US16583518
公开号:
US20200016079A1
申请日:
2019.09.26
申请国别(地区):
US
年份:
2020
代理人:
摘要:
An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.
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