ХОЛЬБАУМ Андреас (DE),ХЮЭЛЬСМАЙЕР Мартин (DE),ГИЛЛЕ Хендрик (DE),МАНТРИПРАГАДА Санкарам Бхима (US),КЭМПБЕЛЛ Кэтлин Мари (US)
申请号：
RU2012107812/15
公开号：
RU2012107812A
申请日:
2010.08.05
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. Pharmaceutical composition for the controlled release of lipocalin mutein, containing lipocalin mutein or its conjugate in combination with a polymer, lipid or liposome. The pharmaceutical composition according to claim 1, characterized in that the lipocalin mutein or its conjugate is encapsulated in the liposome. The pharmaceutical composition according to claim 2, characterized in that the liposomes are dispersed or emulsified in an aqueous basic medium. The pharmaceutical composition according to claim 1, characterized in that the polymer is a biodegradable polymer. The pharmaceutical composition according to claim 4, characterized in that the biodegradable polymer is selected from the group consisting of polyhydroxy acids, polylactides, polyglycolides, copolymers of polylactide and polyglycolide, polylactic acids, polyglycolic acids, copolymers of lactic and glycolic acids, polycaprolactones, polycarbonates, polyamide polyamides polyamino acids, polyorthoesters, polyacetyls, polycyanoacrylates, polyethers, polydioxanones, polyalkylenealkylates, copolymers of polyethylene glycol and polylactides or poly (varnish glycolides), biodegradable polyurethanes and certain types of proteins and polysaccharide polymers, as well as their mixtures, copolymers and derivatives. 6. The pharmaceutical composition according to claim 5, wherein the biodegradable polymer is selected from the group consisting of polyhydroxy acids, polylactic acids, polylactides, polyglycolides, polyglycolic acids and their copolymers, as well as their derivatives. The pharmaceutical composition according to claim 5 or 6, characterized in that the biodegradable polymer is selected from the group consisting of polyanhydrides, poly1. Фармацевтическая композиция для контролируемого высвобождения мутеина липокалина, содержащая мутеин липокалина или его конъюгат в комбинации с полимером, липидом или липосомой.2. Фармацевтическая композиция по п.1, отличающаяся тем, что мутеин липокалина или его конъюга
