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ПРИМЕНЕНИЕ АНТИСМЫСЛОВОГО ОЛИГОНУКЛЕОТИДА В КАЧЕСТВЕ СРЕДСТВА ДЛЯ ЛЕЧЕНИЯ БОЛЬНЫХ СО ЗЛОКАЧЕСТВЕННЫМИ НОВООБРАЗОВАНИЯМИ
专利权人:
MUKHAMETZHANOV; Kairberly
发明人:
MUKHAMETZHANOV, Kairberly,МУХАМЕГЖАНОВ, Каирберлы
申请号:
KZKZ2017/000003
公开号:
WO2018/174696A1
申请日:
2017.03.18
申请国别(地区):
WO
年份:
2018
代理人:
摘要:
In a diseased organism, normal cells and cancer cells compete for glucose and amino acids. In the third and fourth stages of disease, the tumour tissues intensively absorb glucose and amino acids, and normal cells are deprived of the opportunity to use these sources of energy and building blocks for protein synthesis (Shapot V.S., Biokhimicheskie aspekty opukholevogo rosta, Moscow, Meditsina, 1975, page 304). Malignant neoplasms exhibit hyperproduction of certain proteins. In order to suppress the growth and development of a malignant neoplasm, the synthesis of such proteins must be stopped. To do this, the amino acid sequence of the protein must be known. Antisense mRNA can then be preprepared to block the synthesis of the protein in question (Glick G., Pasternak, Molekulyarnaya biotekhnologiya, Moscow, Mir, 2002, page 504). In relatively long mRNA containing information about all of the amino acids necessary to form a new molecule of a protein there is only one AUG codon from which protein synthesis starts (Stryer L., Biokhimiya, vol. 3, Moscow, Mir, 1985, page 400). When this initiation codon is blocked by an antisense oligonucleotide, the process of formation of any protein should be disrupted. The technical result is that of suppressing the synthesis of proteins having any amino acid sequence, and thus providing effective treatment for patients with malignant neoplasms. The use of an antisense oligonucleotide makes it possible to suppress the synthesis of any proteins in tumour tissues and thus to stop the reproduction of rapidly developing cancer cells and also the use of glucose and amino acids in tumour cells.Entre les cellules normales et cancéreuses dun organisme malade se produit une compétition pour la possession du glucose et des acides aminés. Dans le troisième et quatrième développement de la maladie, les tissus tumoraux absorbent intensivement le glucose et les acides aminés, et les cellules normales nont plus la possibilité dutilser ces sources déne
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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