SRINIVAS, PATHI, L,RAO, DHARMARAJ, RAMACHANDRA,KANKAN, RAJENDRA, NARAYANRAO
申请号：
NZ57563607
公开号：
NZ575636A
申请日:
2007.09.28
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed herein is a process for isolating 3-methyl-8-aminocarbonyl-imidazo[5,1-d]-1,2,3,5-terazin-4(3H)-one (temozolomide)comprising diazotizing a compound of formula IIA, wherein R=CH3, in the presence of at least one metal halide, an acid and a source of nitrous acid, wherein the diazotization proceeds by the addition of the compound of formula IIA and the metal halide to a solution containing the source of nitrous acid and subjecting the acidic solution of temozolomide to a counter-current continuous liquid-liquid extraction using water immiscible solvent.
