N- [4- (quinolin-4-yloxy) cyclohexyl (methyl)] (hetero) arylcarboxamides as androgen receptor antagonists, production and uses thereof as medicinal products
NGUYEN, Duy,KÜNZER, Hermann,FAUS GIMENEZ, Hortensia,BADER, Benjamin,KÖHR, Silke,FRITSCH, Martin
申请号：
ES13731325
公开号：
ES2609455T3
申请日:
2013.06.24
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of general formula (I) ** Formula ** in which R1 represents H, cyano, fluorine, chlorine or bromine； A represents 5-membered phenyl or heteroaryl, in which this phenyl or this 5-membered heteroaryl is optionally substituted by one, two or three substituents which are independently selected from each other: halogen, cyano, alkyl, haloalkyl, cycloalkyl, heterocyclyl, hydroxyl, alkoxy, fluoroalkoxy, cycloalkyloxy, amino, alkylamino, dialkylamino, cycloalkylamino, alkylcycloalkylamino, dicycloalkylamino, alkylcarbonylamino, cycloalkylcarbonylamino, alkyl-sulfanyl, cycloalkylsulfanyl, alkylsulfonyl, cycloalkylsyl, alkylsulfonylsyl, alkylsulfonyl, cycloalkylsyl, alkylsulfonyl, cycloalkylsyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonylsyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl, alkylsulfonyl terms alkoxycarbonyl-； n>； = 0, 1 or 2； or one of its salts, or its solvates or the solvates of its salts.Compuesto de fórmula general (I)**Fórmula** en la que R1 representa H, ciano, flúor, cloro o bromo； A representa fenilo o heteroarilo de 5 miembros, en los que este fenilo o este heteroarilo de 5 miembros está opcionalmente sustituido por uno, dos o tres sustituyentes que se eligen en forma independiente uno del otro: halógeno, ciano, alquilo, haloalquilo, cicloalquilo, heterociclilo, hidroxilo, alcoxilo, fluoroalcoxilo, cicloalquiloxilo, amino, alquilamino, dialquilamino, cicloalquilamino, alquilcicloalquilamino, dicicloalquilamino, alquilcarbonilamino, cicloalquilcarbonilamino, alquil- sulfanilo, cicloalquilsulfanilo, alquilsulfonilo, cicloalquilsulfonilo, aminosulfonilo, alquilaminosulfonilo, cicloalquilaminosulfonilo； alcoxicarbonilo-； n >；= 0, 1 o 2； o una de sus sales, o sus solvatos o los solvatos de sus sales.
