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Tricyclic thrombin receptor antagonists
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
申请号:
NL300746
公开号:
NL300746I2
申请日:
2015.06.29
申请国别(地区):
NL
年份:
2016
代理人:
摘要:
Claimed is a process for the manufacture of compounds of the following general formula (II): wherein R x represent a group selected from COOCH 2 CH 3 , SO 2 CH 3 , CONHCH 3 , and COCH 3 , comprising the step of reacting the compound of the following formula (±-13) with a compound of the general formula R x -X, wherein X represents a leaving group and wherein R x is as defined above. Also claimed is a process for the manufacture of pharmaceutical compositions comprising compounds of the following formula (II) or pharmaceutically acceptable salts or solvates thereof.
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