Yoon Ji Kim;Mi Kyung Son;Tae Hyoung Kim;Hyun Hee Kwak;Ghun II Lee;Soo Hyung Kang;Byong Moon Kim;Moohi Yoo;Yong Man Park;Hi Chang Yang;Sung Hee Lee
发明人:
Hyun Hee Kwak,Ghun II Lee,Yong Man Park,Mi Kyung Son,Hi Chang Yang,Tae Hyoung Kim,Yoon Ji Kim,Byong Moon Kim,Sung Hee Lee,Soo Hyung Kang,Moohi Yoo
申请号：
US12595434
公开号：
US08282990B2
申请日:
2008.04.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are biodegradable microspheres, capable of releasing a glucose-regulating peptide in a controlled manner, comprising a biodegradable polymer carrier with the glucose -regulating peptide encapsulated therein, and methods for the preparation thereof. In addition to ensuring high encapsulation efficiency and high stability of the encapsulated drug, the microspheres shows neither an initial burst effect nor incomplete release and allows the zero -order release of drugs over a prolonged period of time, thus improving the therapeutic effect of the drug.
