The method of solid, biodegradable graft is formed in situ in vivo the present invention provides through applicating liquid pharmaceutical composition, the composition of liquid medicine includes a effective amount of biocompatible, water-insoluble, biodegradable polymer and a effective amount of therapeutic peptide modified by one or more lipophilicitys or amphipathic some covalent, and the polymer and therapeutic peptide are dissolved or dispersed in biocompatible, water-soluble organic solvent. The present invention also provides relevant composition and methods.本發明提供通過施用液體藥物組合物在體內原位形成固體的、可生物降解的移植物的方法，所述液體藥物組合物包括有效量的生物相容的、水不溶的、可生物降解的聚合物和有效量的被一個或多個親脂性或兩親性部分共價修飾的治療性肽，所述聚合物和治療性肽是溶解或分散在生物相容的、水溶性的有機溶劑中的。本發明還提供相關的組合物和方法。
