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הרכבים הכוללים כלופידוגרל וסולפואלקיל אתר ציקלודקסטרין והשימוש בהן
专利权人:
CYDEX PHARMACEUTICALS INC.
发明人:
申请号:
IL20177609
公开号:
IL201776A
申请日:
2009.10.27
申请国别(地区):
IL
年份:
2016
代理人:
摘要:
The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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