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Pharmaceutical removal of neuronal extensions from a degenerating disc
专利权人:
Josee Roy
发明人:
Josee Roy,Susan J. Drapeau,Jeffrey C. Marx
申请号:
US11413363
公开号:
US08916611B2
申请日:
2006.04.28
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
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