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METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE
专利权人:
DUKE UNIVERSITY
发明人:
Thomas F. Tedder,Ayumi Yoshizaki,Tomomitsu Miyagaki,Evgueni Kountikov,Jonathan C. Poe
申请号:
US16825757
公开号:
US20200283727A1
申请日:
2020.03.20
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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