Thomas F. Tedder,Ayumi Yoshizaki,Tomomitsu Miyagaki,Evgueni Kountikov,Jonathan C. Poe
申请号：
US16000604
公开号：
US20180291340A1
申请日:
2018.06.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
