ВАН ТОЛ Эрик А.Ф.,РАССЕЛЛ Вильям Михаэль,ХЕРЦ Удо,РЕНЦ Гарольд,ГАРН Холгер,БРААКСМА Мачтелт,ВАН ДЕР ВЕРФ Мария Иоанна,ОВЕРКАМП Карин М.
申请号：
RU2012114190
公开号：
RU2012114190A
申请日:
2010.09.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A composition for use in the treatment or prevention of allergic diseases, comprising a protein mixture, said composition obtained from a culture supernatant at a late exponential phase of the LGG batch culture process. 2. The composition according to claim 1, obtained by a method comprising the steps of (a) subjecting LGG to cultivation in an acceptable culture medium using a batch process； (b) collecting the culture supernatant at a late exponential phase of the culture step, the phase being determined relative to the second half of the time between the lag phase and the stationary phase of the LGG batch culture process； (c) optionally removing low molecular weight components from the supernatant so as to maintain a molecular weight of the components above 6 kDa； (d) removing liquid contents from the culture supernatant to obtain a composition. 3. The composition of claim 1, wherein the late exponential phase is determined relative to the last quarter of the time between the lag phase and the stationary phase of the LGG batch cultivation process, preferably 0.75-0.85 time elapsed in the exponential phase. The composition of claim 1, wherein the batch cultivation of LGG is performed in a culture medium without Tween 80, a medium optionally containing an oil ingredient selected from the group consisting of oleic acid, linseed oil, olive oil, rapeseed oil, sunflower oil, and mixtures thereof. . The composition according to claim 1, wherein the batch culture of LGG is carried out at a neutral pH, preferably pH 6, at a physiological temperature, preferably 37 ° C. The composition according to claim 1, in dry form1. Композиция для применения в лечении или профилактике аллергических заболеваний, содержащая белковую смесь, причем указанная композиция получена из культурального супернатанта на поздней экспоненциальной фазе процесса периодического культивирования LGG.2. Композиция по п.1, полученная способом, включающим этапы (а) подвергания LGG культивированию в приемле
