The invention discloses the particles that can be discharged for a long time of the somatostatin analogues comprising being embedded in biocompatibility pharmaceutical acceptable polymer matrix, and the pharmaceutical composition comprising such particle.本發明公開了包含包埋在生物相容性可藥用聚合物基質中的生長激素釋放抑制因子類似物的可長期釋放的微粒,以及包含這樣的微粒的藥物組合物。