A method for determining compatibility of bioactive agents (i.e. supplement formulation components, pharmacological agents, etc.), comprising (i) determining compatibility by and between components contained in a supplement formulation, i.e. vitamins and/or minerals, (ii) determining compatibility by and between the formulation components and the body, and (iii) determining compatibility by and between the formulation components and pharmacological agents, i.e. prescribed and over-the-counter medications, and formulations derived therefrom.