JOHNSSON, MARKUS,JOABSSON, FREDRIK,TIBERG, FREDRIK
申请号：
ES05767909
公开号：
ES2383530T3
申请日:
2005.08.04
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A composition, comprising a) at least one mono acyl lipid, wherein said component a) consists of a mono acyl lipid or a mixture of mono acyl lipids forming a micellar or laminar phase after coming into contact with water； b) at least one diacyl glycerol, at least one tocopherol or mixtures thereof； and c) at least one fragmentation agent, wherein component c) is selected from polymer fragmentation agents, polyol surfactants, proteins, anionic surfactants, cationic surfactants and mixtures thereof； and optionally an active agent, in which the composition is capable of self-dispersion to provide colloidal non-lamellar particles after coming into contact with an aqueous fluid； wherein said non-laminar particles are liquid crystalline particles of normal or inverted cubic phase, hexagonal or L3 or any combination thereof； where a / (a + b), which is the weight ratio of component a) to the sum of components a) and b), is between 0.2 and 0.9； c / (a + b + c), which is the ratio by weight of component c) to the sum of components a), b) and c) is between 0.01 and 0.3； and in which a composition can be considered self-dispersing if the solvent-free composition is capable of forming a dispersion of non-laminar particles with a monomodal size distribution with an average particle size of no more than 5 μm and an amplitude of the distribution of no more than 3 μm at half the height by a method comprising forming a 5% solution p in an aqueous fluid (such as water or aqueous buffer) and stirring for up to 12 hours at 350 rpm.Una composición, que comprende a) al menos un monoacil-lípido, en que dicho componente a) consiste en un monoacil-lípido o una mezcla de monoacil-lípidos que forma una fase micelar o laminar tras entrar en contacto con agua； b) al menos un diacil-glicerol, al menos un tocoferol o sus mezclas； y c) al menos un agente de fragmentación, en el que el componente c) se selecciona entre agentes de fragmentación polímeros, tensioactivos de polioles, proteínas, tensio
