The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.本發明係關於新穎磺醯脲及磺醯基硫脲化合物及相關化合物及其在治療對諸如IL-1β及IL-18等細胞介素之調節、NLRP3之調節或NLRP3或發炎過程之相關組分之活化之抑制有反應的疾病或病況中之用途。