An emulsion composition includes prostaglandin E 1 (PGE 1 ), a phospholipid with a high purity and a non-proton-providing surfactant that improves stability of PGE 1 . Embodiments of the emulsion composition include an effective amount of PGE 1 , about 1 % to about 30% (w/w) of a pharmaceutically acceptable oil as an oil base based on the weight of the emulsion composition, about 1% to about 30% (w/w) of a phospholipid with a high purity based on the weight of the oil base, about 1.6% to about 40% (w/w) of a non-proton-providing surfactant based on the weight of the oil base, and the balance of the emulsion composition being water.
