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Implantable inflatable bioresorbable polymer
专利权人:
Assistance Publique Hôpitaux De Paris;Centre National de la Recherche Scientifique;Université Paris Diderot - Paris 7;Occlugel
发明人:
MOINE, Laurence,LAURENT, Alexandre,WASSEF, Michel,BEDOUET, Laurent,LOUGUET, Stéphanie,VERRET, Valentin,SERVAIS, Emeline
申请号:
ES12707789
公开号:
ES2632769T3
申请日:
2012.03.09
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Crosslinked polymer that can be obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2>; = CR1) CO-K (I) in which: - K represents OZ or NH-Z , representing Z (CR2R3) m-CH3, (CH2-CH2-O) mH, (CH2-CH2-O) m-CH3, (CH2) m-NR4R5, with m representing an integer from 1 to 30; - R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50 mol%, advantageously between 1 and 30 mol%, more advantageously between 1 and 20 mol% of a cyclic monomer having an exomethylene group of formula (II): * * Formula ** in which: - R6, R7, R8 and R9 independently represent H or an aryl group of C5-C7 or R6 and R9 are absent and R7 and R8 form together with the carbon atom to which a group is attached C5-C7 aryl; - i and j independently represent an integer selected between 0 and 2; - X represents O or X is not present and in the latter case, CR6R7 and CR8R9 are linked by a single CC link and (iii) at least one bioabsorbable block copolymer crosslinker, in which the bioabsorbable block copolymer crosslinker is linear and has groups (CH2>; = (CR10)) - at both ends, in which R10 independently represents H or a C1-C6 alkyl.Polímero reticulado que se puede obtener a partir de la polimerización de: (i) por lo menos un monómero de fórmula (I) (CH2>;=CR1)CO-K (I) en la que: - K representa O-Z o NH-Z, representando Z (CR2R3)m-CH3, (CH2-CH2-O)m-H, (CH2-CH2-O)m-CH3, (CH2)m-NR4R5, con m representando un número entero de 1 a 30; - R1, R2, R3, R4 y R5 representan independientemente H o un alquilo de C1-C6; (ii) por lo menos entre 0,1 y 50% en moles, ventajosamente entre 1 y 30% en moles, más ventajosamente entre 1 y 20% en moles de un monómero cíclico que presenta un grupo exometileno de fórmula (II):**Fórmula** en la que: - R6, R7, R8 y R9 representan independientemente H o un grupo arilo de C5-C7 o R6 y R9 están ausentes y R7 y R8 forman junto con el átomo de carbono al que están enlazados un grupo arilo de C5-C7; - i y j representan i
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