A human body supporting and lifting machine on a bed is provided with a guide tube (13) supported by a bed body (9) at a laterally leaning frame (8) of a long side of a bed frame (7), and at one side of a part of the bed corresponding to shoulders and back, buttocks, and knees of a lying person under nursing care. An inner hole of the guide tube (13) is matched with a lift rod (6), and an upper end of the lift rod (6) can be fixed with a support handle (2) of a lift and support member (4). During working, the lift and support member (4) or a fabric (38) is arranged under the body of the person under nursing care, and a drive mechanism acts on the lift rod (6), so as to lift up the person under nursing care through the lift and support member (4) or the fabric (38), so that a nurse can conveniently complete nursing work of replacing a bed sheet and bedding and bathing the person under nursing care, can conveniently pick and place an insertion basin, and wash the person under nursing care partially and air below the body of the bedridden person under nursing care can circulate, thereby avoiding generation of bedsore. The human body supporting and lifting machine on a bed effectively solves a series of problems in nursing work for the elderly and patients, thereby alleviating the nursing strength and providing comprehensive nursing for persons under nursing care.