A process for preparing an extract of Momordica charantia, including: a) preparing crude juice b) filtering to obtain filtered juice c) modifying pH d) allowing the pH modified juice to stabilize e) neutralizing the stabilized juice f) allowing the neutralized juice to stand for 20-30 minutes g) rechecking the pH level and h) drying the juice to obtain the extract. The process said above is simple, cost effective, which does not employ any harmful organic solvents and which enhances the potency of the constituents. A simple and potent formulation showing anti-diabetic activity comprising active constituents of Momordica charantia is also provided.본 개시는 간단하고 비용 효과적이며, 해로운 유기용매를 전혀 사용하지 않으면서도 성분의 효능을 향상시킬 수 있는 여주의 유효성분 추출 방법을 제공한다. 본 개시는 또한 여주의 유효성분을 포함하는 항당뇨 활성을 보이는 간단하고 효능이 강한 제제를 제공한다.