At present, protein refers to the protein associated with sclerosing or sclerosing substance and TNF, as well as the components and methods used in cells, tissues, samples and compounds for the treatment, prevention and diagnosis of sclerosing related diseases and for the detection of sclerosing or sclerosing substance and TNF. Nucleic acids, vectors, host cells and pharmaceutical components.La presente se refiere a proteínas que se enlazan a esclerostina o esclerostina y TNF, junto con su uso en la composición y métodos para tratar, prevenir y diagnosticar enfermedades relacionadas con la esclerostina y para detectar esclerostina o esclerostina y TNF en células, tejidos, muestras y composiciones. El ácido nucleico, vector, célula huésped y composición farmacéutica.