Heer Jag Paul,Jackson Victoria Elizabeth,Kroeplien Boris,Lecomte Fabien Claude,Porter John Robert
申请号:
US201415038287
公开号:
US10093652(B2)
申请日:
2014.12.08
申请国别(地区):
美国
年份:
2018
代理人:
McDonnell Boehnen Hulbert & Berghoff LLP
摘要:
A series of substituted 4,5,6,7-tetrahydrobenzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.