THE PROCESS FOR PREPARATION OF CLONAZEPAM

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专利权人:

发明人:

DR ANIL MAHADEV NAIK,DR SHRIKANT DATTATRAYA SAWANT,DR GIRISH ARVIND KAVISHWAR,DR SMITA GIRISH KAVISHWAR

申请号：

IN1354/MUM/2011

公开号：

IN2011MU01354A

申请日:

2011.04.29

申请国别(地区):

IN

年份:

2012

代理人:

摘要：

The invention relates to improved process for making 5-(2-chlorophenyI)-l,3-dihydro-7-nitrobenzo(l,4)-diazepin-2-one namely Clonazepam from reacting 2-(2-chloroacetamido)-5-2-nitrobenzophenone with hexamine to from 2-(2-chloroacetamido)-5-2-nitrobenzophenone -Hexamine complex which further treated in presence of aq. solution of ammonium chloride in polar protic solvent to obtain clonazepam which finally crystallize in ester solvent to yield pure clonazepam.

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