INGRID VAN DEN NIEUWENHOF;CRUCELL HOLLAND B.V.;CORNELIS ERIK HACK;ELISABETH C.M. BRINKMAN
发明人:
ELISABETH C.M. BRINKMAN,CORNELIS ERIK HACK,INGRID VAN DEN NIEUWENHOF
申请号：
IL21553711
公开号：
IL215537A
申请日:
2011.10.04
申请国别(地区):
IL
年份:
2016
代理人:
摘要：
The present invention relates recombinant human &alpha；1-antitrypsin (rhAAT) comprising N-linked glycans, wherein at least 10% of said N-linked glycans are tetra-antennary glycans； and the degree of capping with sialic acid on said N-linked glycans (Z/A) is at least 50%. The invention further relates to rhAAT for use as a medicament, in particular for use in the prevention and/or treatment of a disease associated with AAT deficiency, and/or a disease involving neutrophil-mediated tissue damage.
