Cornelis E. Hack;Ingrid Van Den Nieuwenhof;Elisabeth C.M. Brinkman
发明人:
Elisabeth C.M. Brinkman,Cornelis E. Hack,Ingrid Van Den Nieuwenhof
申请号：
US13138912
公开号：
US20120214747A1
申请日:
2010.04.20
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates recombinant human α1-antitrypsin (rhAAT) comprising N-linked glycans, wherein at least 10% of said N-linked glycans are tetra-antennary glycans； and the degree of capping with sialic acid on said N-linked glycans (Z/A) is at least 50%. The invention further relates to rhAAT for use as a medicament, in particular for use in the prevention and/or treatment of a disease associated with AAT deficiency, and/or a disease involving neutrophil-mediated tissue damage.
