Christian Poulsen,Kasper Huus,Frantisek Hubalek,Dorte Bjerre Steensgaard,Svend Havelund
申请号：
US12664156
公开号：
US09034818B2
申请日:
2008.06.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention concerns a soluble pharmaceutical formulation comprising an insulin derivative wherein the formulation further comprises more than 4 zinc atoms per 6 molecules of the insulin derivative, and a citric acid monohydrate and/or a histidine compound used in an amount sufficient to increase the tendency of the insulin derivative to self-associate into dodecamers. The invention further comprises a process for preparing the soluble pharmaceutical formulation.
