Patrick William Garibay,Thomas Hoeg-Jensen,Ib Jonassen,Svend Havelund,Peter Madsen,Palle Jakobsen
申请号：
US13506292
公开号：
US20120208749A1
申请日:
2012.04.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is related to insulin derivatives having a side chain attached either to the α-amino group of the N-terminal amino acid residue of B chain or to an ε-amino group of a Lys residue present in the B chain of the parent insulin molecule via an amide bond which side chain comprises one or more residues of ethyleneglycol, propyleneglycol and/or butyleneglycol containing independently at each termini a group selected from —NH2 and —COOH a fatty diacid moiety with 4 to 22 carbon atoms, at least one free carboxylic acid group or a group which is negatively charged at neutral pH and possible linkers which link the individual components in the side chain together via amide or ether bonds, said linkers optionally comprising a free carboxylic acid group.
